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Muscle preservation during caloric deficit requires a mechanical stimulus that tells the body "these muscles are being used, do not break them down for energy." Without that signal, up to 40% of weight lost can come from lean tissue rather than fat

Therefore, even though we obtained significant increases in the hTERT mRNA expression for 21NT and BT474 after epitalon treatment, lower levels of the fully functional variant may have been produced hence no correlation between mRNA levels and telomerase enzyme activity was observed

Multiple protein feedings ensure amino acids remain available throughout the day

doi:10.4093/dmj.2023.0164 22

[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

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